Fan theories (volume six)

Family Guy is a sequel to the Dune saga, which is itself a sequel to the Odyssey saga. I was joking about this at first but it makes perfect sense. Stewie Griffin says "deuce" a lot (as in "what the..") which could be connected with the change in religious sensibilities in the final Odyssey novel 3001:The Final Odyssey i.e., they say "deuce" instead of God.

The war against the monolith machines could be referred to in Dune. Which also has talking toddlers with a killer instinct and advanced technology! 

Family Guy represents a Matrix-like experiment to see how humanity would develop without the influence of the monoliths and space travel. Earth was re-settled and its inhabitants led to believe that it is the early twenty-first century. The population consists entirely of Gholas, who are reborn by human women. These Gholas initially remember their previous lives (those of the clone donor) but forget them as they mature, thus explaining how Stewie can be fully sentient even before being born. Creatures such as Brian Griffin developed during the Spice Famine, which also produced the feline Futars. So he is not actually a dog. Or he might be descended from dogs originally.